Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial†
Identifieur interne : 003996 ( Main/Exploration ); précédent : 003995; suivant : 003997Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial†
Auteurs : Jean-Claude Tardif ; Christie M. Ballantyne ; Philip Barter ; Jean-Louis Dasseux ; Zahi A. Fayad ; Marie-Claude Guertin ; John J. P. Kastelein ; Constance Keyserling ; Heather Klepp ; Wolfgang Koenig ; Philippe L. L'Allier ; Jacques Lespérance ; Thomas F. Lüscher ; John F. Paolini ; Ahmed Tawakol ; David D. WatersSource :
- European Heart Journal [ 0195-668X ] ; 2014.
Abstract
High-density lipoproteins (HDLs) have several potentially protective vascular effects. Most clinical studies of therapies targeting HDL have failed to show benefits vs. placebo.
To investigate the effects of an HDL-mimetic agent on atherosclerosis by intravascular ultrasonography (IVUS) and quantitative coronary angiography (QCA).
A prospective, double-blinded, randomized trial was conducted at 51 centres in the USA, the Netherlands, Canada, and France. Intravascular ultrasonography and QCA were performed to assess coronary atherosclerosis at baseline and 3 (2–5) weeks after the last study infusion.
Five hundred and seven patients were randomized; 417 and 461 had paired IVUS and QCA measurements, respectively.
Patients were randomized to receive 6 weekly infusions of placebo, 3 mg/kg, 6 mg/kg, or 12 mg/kg CER-001.
The primary efficacy parameter was the nominal change in the total atheroma volume. Nominal changes in per cent atheroma volume on IVUS and coronary scores on QCA were also pre-specified endpoints.
The nominal change in the total atheroma volume (adjusted means) was −2.71, −3.13, −1.50, and −3.05 mm3 with placebo, CER-001 3 mg/kg, 6 mg/kg, and 12 mg/kg, respectively (primary analysis of 12 mg/kg vs. placebo:
CER-001 infusions did not reduce coronary atherosclerosis on IVUS and QCA when compared with placebo. Whether CER-001 administered in other regimens or to other populations could favourably affect atherosclerosis must await further study.
Name of the trial registry: Clinicaltrials.gov; Registry's URL:
Url:
DOI: 10.1093/eurheartj/ehu171
PubMed: 24780501
PubMed Central: 4258222
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002462
- to stream Pmc, to step Curation: 002312
- to stream Pmc, to step Checkpoint: 001621
- to stream Ncbi, to step Merge: 001999
- to stream Ncbi, to step Curation: 001999
- to stream Ncbi, to step Checkpoint: 001999
- to stream Main, to step Merge: 003A38
- to stream Main, to step Curation: 003996
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial<sup><xref ref-type="author-notes" rid="AN1">†</xref></sup></title><author><name sortKey="Tardif, Jean Claude" sort="Tardif, Jean Claude" uniqKey="Tardif J" first="Jean-Claude" last="Tardif">Jean-Claude Tardif</name></author><author><name sortKey="Ballantyne, Christie M" sort="Ballantyne, Christie M" uniqKey="Ballantyne C" first="Christie M." last="Ballantyne">Christie M. Ballantyne</name></author><author><name sortKey="Barter, Philip" sort="Barter, Philip" uniqKey="Barter P" first="Philip" last="Barter">Philip Barter</name></author><author><name sortKey="Dasseux, Jean Louis" sort="Dasseux, Jean Louis" uniqKey="Dasseux J" first="Jean-Louis" last="Dasseux">Jean-Louis Dasseux</name></author><author><name sortKey="Fayad, Zahi A" sort="Fayad, Zahi A" uniqKey="Fayad Z" first="Zahi A." last="Fayad">Zahi A. Fayad</name></author><author><name sortKey="Guertin, Marie Claude" sort="Guertin, Marie Claude" uniqKey="Guertin M" first="Marie-Claude" last="Guertin">Marie-Claude Guertin</name></author><author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J. P." last="Kastelein">John J. P. Kastelein</name></author><author><name sortKey="Keyserling, Constance" sort="Keyserling, Constance" uniqKey="Keyserling C" first="Constance" last="Keyserling">Constance Keyserling</name></author><author><name sortKey="Klepp, Heather" sort="Klepp, Heather" uniqKey="Klepp H" first="Heather" last="Klepp">Heather Klepp</name></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name></author><author><name sortKey="L Allier, Philippe L" sort="L Allier, Philippe L" uniqKey="L Allier P" first="Philippe L." last="L'Allier">Philippe L. L'Allier</name></author><author><name sortKey="Lesperance, Jacques" sort="Lesperance, Jacques" uniqKey="Lesperance J" first="Jacques" last="Lespérance">Jacques Lespérance</name></author><author><name sortKey="Luscher, Thomas F" sort="Luscher, Thomas F" uniqKey="Luscher T" first="Thomas F." last="Lüscher">Thomas F. Lüscher</name></author><author><name sortKey="Paolini, John F" sort="Paolini, John F" uniqKey="Paolini J" first="John F." last="Paolini">John F. Paolini</name></author><author><name sortKey="Tawakol, Ahmed" sort="Tawakol, Ahmed" uniqKey="Tawakol A" first="Ahmed" last="Tawakol">Ahmed Tawakol</name></author><author><name sortKey="Waters, David D" sort="Waters, David D" uniqKey="Waters D" first="David D." last="Waters">David D. Waters</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24780501</idno><idno type="pmc">4258222</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258222</idno><idno type="RBID">PMC:4258222</idno><idno type="doi">10.1093/eurheartj/ehu171</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002462</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002462</idno><idno type="wicri:Area/Pmc/Curation">002312</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002312</idno><idno type="wicri:Area/Pmc/Checkpoint">001621</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001621</idno><idno type="wicri:Area/Ncbi/Merge">001999</idno><idno type="wicri:Area/Ncbi/Curation">001999</idno><idno type="wicri:Area/Ncbi/Checkpoint">001999</idno><idno type="wicri:doubleKey">0195-668X:2014:Tardif J:effects:of:the</idno><idno type="wicri:Area/Main/Merge">003A38</idno><idno type="wicri:Area/Main/Curation">003996</idno><idno type="wicri:Area/Main/Exploration">003996</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial<sup><xref ref-type="author-notes" rid="AN1">†</xref></sup></title><author><name sortKey="Tardif, Jean Claude" sort="Tardif, Jean Claude" uniqKey="Tardif J" first="Jean-Claude" last="Tardif">Jean-Claude Tardif</name></author><author><name sortKey="Ballantyne, Christie M" sort="Ballantyne, Christie M" uniqKey="Ballantyne C" first="Christie M." last="Ballantyne">Christie M. Ballantyne</name></author><author><name sortKey="Barter, Philip" sort="Barter, Philip" uniqKey="Barter P" first="Philip" last="Barter">Philip Barter</name></author><author><name sortKey="Dasseux, Jean Louis" sort="Dasseux, Jean Louis" uniqKey="Dasseux J" first="Jean-Louis" last="Dasseux">Jean-Louis Dasseux</name></author><author><name sortKey="Fayad, Zahi A" sort="Fayad, Zahi A" uniqKey="Fayad Z" first="Zahi A." last="Fayad">Zahi A. Fayad</name></author><author><name sortKey="Guertin, Marie Claude" sort="Guertin, Marie Claude" uniqKey="Guertin M" first="Marie-Claude" last="Guertin">Marie-Claude Guertin</name></author><author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J. P." last="Kastelein">John J. P. Kastelein</name></author><author><name sortKey="Keyserling, Constance" sort="Keyserling, Constance" uniqKey="Keyserling C" first="Constance" last="Keyserling">Constance Keyserling</name></author><author><name sortKey="Klepp, Heather" sort="Klepp, Heather" uniqKey="Klepp H" first="Heather" last="Klepp">Heather Klepp</name></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name></author><author><name sortKey="L Allier, Philippe L" sort="L Allier, Philippe L" uniqKey="L Allier P" first="Philippe L." last="L'Allier">Philippe L. L'Allier</name></author><author><name sortKey="Lesperance, Jacques" sort="Lesperance, Jacques" uniqKey="Lesperance J" first="Jacques" last="Lespérance">Jacques Lespérance</name></author><author><name sortKey="Luscher, Thomas F" sort="Luscher, Thomas F" uniqKey="Luscher T" first="Thomas F." last="Lüscher">Thomas F. Lüscher</name></author><author><name sortKey="Paolini, John F" sort="Paolini, John F" uniqKey="Paolini J" first="John F." last="Paolini">John F. Paolini</name></author><author><name sortKey="Tawakol, Ahmed" sort="Tawakol, Ahmed" uniqKey="Tawakol A" first="Ahmed" last="Tawakol">Ahmed Tawakol</name></author><author><name sortKey="Waters, David D" sort="Waters, David D" uniqKey="Waters D" first="David D." last="Waters">David D. Waters</name></author></analytic><series><title level="j">European Heart Journal</title><idno type="ISSN">0195-668X</idno><idno type="eISSN">1522-9645</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Aim</title><p>High-density lipoproteins (HDLs) have several potentially protective vascular effects. Most clinical studies of therapies targeting HDL have failed to show benefits vs. placebo.</p></sec><sec><title>Objective</title><p>To investigate the effects of an HDL-mimetic agent on atherosclerosis by intravascular ultrasonography (IVUS) and quantitative coronary angiography (QCA).</p></sec><sec><title>Design and setting</title><p>A prospective, double-blinded, randomized trial was conducted at 51 centres in the USA, the Netherlands, Canada, and France. Intravascular ultrasonography and QCA were performed to assess coronary atherosclerosis at baseline and 3 (2–5) weeks after the last study infusion.</p></sec><sec><title>Patients</title><p>Five hundred and seven patients were randomized; 417 and 461 had paired IVUS and QCA measurements, respectively.</p></sec><sec><title>Intervention</title><p>Patients were randomized to receive 6 weekly infusions of placebo, 3 mg/kg, 6 mg/kg, or 12 mg/kg CER-001.</p></sec><sec><title>Main outcome measures</title><p>The primary efficacy parameter was the nominal change in the total atheroma volume. Nominal changes in per cent atheroma volume on IVUS and coronary scores on QCA were also pre-specified endpoints.</p></sec><sec><title>Results</title><p>The nominal change in the total atheroma volume (adjusted means) was −2.71, −3.13, −1.50, and −3.05 mm<sup>3</sup> with placebo, CER-001 3 mg/kg, 6 mg/kg, and 12 mg/kg, respectively (primary analysis of 12 mg/kg vs. placebo: <italic>P</italic> = 0.81). There was also no difference among groups for the nominal change in per cent atheroma volume (0.02, −0.02, 0.01, and 0.19%; nominal <italic>P</italic> = 0.53 for 12 mg/kg vs. placebo). Change in the coronary artery score was −0.022, −0.036, −0.022, and −0.015 mm (nominal <italic>P</italic> = 0.25, 0.99, 0.55), and change in the cumulative coronary stenosis score was −0.51, 2.65, 0.71, and −0.77% (compared with placebo, nominal <italic>P</italic> = 0.85 for 12 mg/kg and nominal <italic>P</italic> = 0.01 for 3 mg/kg). The number of patients with major cardiovascular events was 10 (8.3%), 16 (13.3%), 17 (13.7%), and 12 (9.8%) in the four groups.</p></sec><sec><title>Conclusion</title><p>CER-001 infusions did not reduce coronary atherosclerosis on IVUS and QCA when compared with placebo. Whether CER-001 administered in other regimens or to other populations could favourably affect atherosclerosis must await further study.</p><p>Name of the trial registry: Clinicaltrials.gov; Registry's URL: <uri xlink:type="simple" xlink:href="http://clinicaltrials.gov/ct2/show/NCT01201837?term=cer-001&rank=2">http://clinicaltrials.gov/ct2/show/NCT01201837?term=cer-001&rank=2</uri>; Trial registration number: NCT01201837.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cannon, Cp" uniqKey="Cannon C">CP Cannon</name></author><author><name sortKey="Braunwald, E" uniqKey="Braunwald E">E Braunwald</name></author><author><name sortKey="Mccabe, Ch" uniqKey="Mccabe C">CH McCabe</name></author><author><name sortKey="Rader, Dj" uniqKey="Rader D">DJ Rader</name></author><author><name sortKey="Rouleau, Jl" uniqKey="Rouleau J">JL Rouleau</name></author><author><name sortKey="Belder, R" uniqKey="Belder R">R Belder</name></author><author><name sortKey="Joyal, Sv" uniqKey="Joyal S">SV Joyal</name></author><author><name sortKey="Hill, Ka" uniqKey="Hill K">KA Hill</name></author><author><name sortKey="Pfeffer, Ma" uniqKey="Pfeffer M">MA Pfeffer</name></author><author><name sortKey="Skene, Am" uniqKey="Skene A">AM Skene</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Boden, We" uniqKey="Boden W">WE Boden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mora, S" uniqKey="Mora S">S Mora</name></author><author><name sortKey="Glynn, Rj" uniqKey="Glynn R">RJ Glynn</name></author><author><name sortKey="Ridker, Pm" uniqKey="Ridker P">PM Ridker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Silbernagel, G" uniqKey="Silbernagel G">G Silbernagel</name></author><author><name sortKey="Schottker, B" uniqKey="Schottker B">B Schöttker</name></author><author><name sortKey="Appelbaum, S" uniqKey="Appelbaum S">S Appelbaum</name></author><author><name sortKey="Scharnagl, H" uniqKey="Scharnagl H">H Scharnagl</name></author><author><name sortKey="Kleber, Me" uniqKey="Kleber M">ME Kleber</name></author><author><name sortKey="Grammer, Tb" uniqKey="Grammer T">TB Grammer</name></author><author><name sortKey="Ritsch, A" uniqKey="Ritsch A">A Ritsch</name></author><author><name sortKey="Mons, U" uniqKey="Mons U">U Mons</name></author><author><name sortKey="Holleczek, B" uniqKey="Holleczek B">B Holleczek</name></author><author><name sortKey="Goliasch, G" uniqKey="Goliasch G">G Goliasch</name></author><author><name sortKey="Niessner, A" uniqKey="Niessner A">A Niessner</name></author><author><name sortKey="Boehm, Bo" uniqKey="Boehm B">BO Boehm</name></author><author><name sortKey="Schnabel, Rb" uniqKey="Schnabel R">RB Schnabel</name></author><author><name sortKey="Brenner, H" uniqKey="Brenner H">H Brenner</name></author><author><name sortKey="Blankenberg, S" uniqKey="Blankenberg S">S Blankenberg</name></author><author><name sortKey="Landmesser, U" uniqKey="Landmesser U">U Landmesser</name></author><author><name sortKey="M Rz, W" uniqKey="M Rz W">W März</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boden, We" uniqKey="Boden W">WE Boden</name></author><author><name sortKey="Probstfield, Jl" uniqKey="Probstfield J">JL Probstfield</name></author><author><name sortKey="Anderson, T" uniqKey="Anderson T">T Anderson</name></author><author><name sortKey="Chaitman, Br" uniqKey="Chaitman B">BR Chaitman</name></author><author><name sortKey="Desvignes Nickens, P" uniqKey="Desvignes Nickens P">P Desvignes-Nickens</name></author><author><name sortKey="Koprowicz, K" uniqKey="Koprowicz K">K Koprowicz</name></author><author><name sortKey="Mcbride, R" uniqKey="Mcbride R">R McBride</name></author><author><name sortKey="Teo, K" uniqKey="Teo K">K Teo</name></author><author><name sortKey="Weintraub, W" uniqKey="Weintraub W">W Weintraub</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Barter, Pj" uniqKey="Barter P">PJ Barter</name></author><author><name sortKey="Caulfield, M" uniqKey="Caulfield M">M Caulfield</name></author><author><name sortKey="Eriksson, M" uniqKey="Eriksson M">M Eriksson</name></author><author><name sortKey="Grundy, Sm" uniqKey="Grundy S">SM Grundy</name></author><author><name sortKey="Kastelein, Jj" uniqKey="Kastelein J">JJ Kastelein</name></author><author><name sortKey="Komajda, M" uniqKey="Komajda M">M Komajda</name></author><author><name sortKey="Lopez Sendon, J" uniqKey="Lopez Sendon J">J Lopez-Sendon</name></author><author><name sortKey="Mosca, L" uniqKey="Mosca L">L Mosca</name></author><author><name sortKey="Tardif, Jc" uniqKey="Tardif J">JC Tardif</name></author><author><name sortKey="Waters, Dd" uniqKey="Waters D">DD Waters</name></author><author><name sortKey="Shear, Cl" uniqKey="Shear C">CL Shear</name></author><author><name sortKey="Revkin, Jh" uniqKey="Revkin J">JH Revkin</name></author><author><name sortKey="Buhr, Ka" uniqKey="Buhr K">KA Buhr</name></author><author><name sortKey="Fisher, Mr" uniqKey="Fisher M">MR Fisher</name></author><author><name sortKey="Tall, Ar" uniqKey="Tall A">AR Tall</name></author><author><name sortKey="Brewer, B" uniqKey="Brewer B">B Brewer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwartz, Gg" uniqKey="Schwartz G">GG Schwartz</name></author><author><name sortKey="Olsson, Ag" uniqKey="Olsson A">AG Olsson</name></author><author><name sortKey="Abt, M" uniqKey="Abt M">M Abt</name></author><author><name sortKey="Ballantyne, Cm" uniqKey="Ballantyne C">CM Ballantyne</name></author><author><name sortKey="Barter, Pj" uniqKey="Barter P">PJ Barter</name></author><author><name sortKey="Brumm, J" uniqKey="Brumm J">J Brumm</name></author><author><name sortKey="Chaitman, Br" uniqKey="Chaitman B">BR Chaitman</name></author><author><name sortKey="Holme, Im" uniqKey="Holme I">IM Holme</name></author><author><name sortKey="Kallend, D" uniqKey="Kallend D">D Kallend</name></author><author><name sortKey="Leiter, La" uniqKey="Leiter L">LA Leiter</name></author><author><name sortKey="Leitersdorf, E" uniqKey="Leitersdorf E">E Leitersdorf</name></author><author><name sortKey="Mcmurray, Jj" uniqKey="Mcmurray J">JJ McMurray</name></author><author><name sortKey="Mundl, H" uniqKey="Mundl H">H Mundl</name></author><author><name sortKey="Nicholls, Sj" uniqKey="Nicholls S">SJ Nicholls</name></author><author><name sortKey="Shah, Pk" uniqKey="Shah P">PK Shah</name></author><author><name sortKey="Tardif, Jc" uniqKey="Tardif J">JC Tardif</name></author><author><name sortKey="Wright, Rs" uniqKey="Wright R">RS Wright</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nissen, Se" uniqKey="Nissen S">SE Nissen</name></author><author><name sortKey="Tsunoda, T" uniqKey="Tsunoda T">T Tsunoda</name></author><author><name sortKey="Tuzcu, Em" uniqKey="Tuzcu E">EM Tuzcu</name></author><author><name sortKey="Schoenhagen, P" uniqKey="Schoenhagen P">P Schoenhagen</name></author><author><name sortKey="Cooper, Cj" uniqKey="Cooper C">CJ Cooper</name></author><author><name sortKey="Yasin, M" uniqKey="Yasin M">M Yasin</name></author><author><name sortKey="Eaton, Gm" uniqKey="Eaton G">GM Eaton</name></author><author><name sortKey="Lauer, Ma" uniqKey="Lauer M">MA Lauer</name></author><author><name sortKey="Sheldon, Ws" uniqKey="Sheldon W">WS Sheldon</name></author><author><name sortKey="Grines, Cl" uniqKey="Grines C">CL Grines</name></author><author><name sortKey="Halpern, S" uniqKey="Halpern S">S Halpern</name></author><author><name sortKey="Crowe, T" uniqKey="Crowe T">T Crowe</name></author><author><name sortKey="Blankenship, Jc" uniqKey="Blankenship J">JC Blankenship</name></author><author><name sortKey="Kerensky, R" uniqKey="Kerensky R">R Kerensky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tardif, Jc" uniqKey="Tardif J">JC Tardif</name></author><author><name sortKey="Gregoire, J" uniqKey="Gregoire J">J Grégoire</name></author><author><name sortKey="L Allier, Pl" uniqKey="L Allier P">PL L'Allier</name></author><author><name sortKey="Ibrahim, R" uniqKey="Ibrahim R">R Ibrahim</name></author><author><name sortKey="Lesperance, J" uniqKey="Lesperance J">J Lespérance</name></author><author><name sortKey="Heinonen, Tm" uniqKey="Heinonen T">TM Heinonen</name></author><author><name sortKey="Kouz, S" uniqKey="Kouz S">S Kouz</name></author><author><name sortKey="Berry, C" uniqKey="Berry C">C Berry</name></author><author><name sortKey="Basser, R" uniqKey="Basser R">R Basser</name></author><author><name sortKey="Lavoie, Ma" uniqKey="Lavoie M">MA Lavoie</name></author><author><name sortKey="Guertin, Mc" uniqKey="Guertin M">MC Guertin</name></author><author><name sortKey="Rodes Cabau, J" uniqKey="Rodes Cabau J">J Rodés-Cabau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Waksman, R" uniqKey="Waksman R">R Waksman</name></author><author><name sortKey="Torguson, R" uniqKey="Torguson R">R Torguson</name></author><author><name sortKey="Kent, Km" uniqKey="Kent K">KM Kent</name></author><author><name sortKey="Pichard, Ad" uniqKey="Pichard A">AD Pichard</name></author><author><name sortKey="Suddath, Wo" uniqKey="Suddath W">WO Suddath</name></author><author><name sortKey="Satler, Lf" uniqKey="Satler L">LF Satler</name></author><author><name sortKey="Martin, Bd" uniqKey="Martin B">BD Martin</name></author><author><name sortKey="Perlman, Tj" uniqKey="Perlman T">TJ Perlman</name></author><author><name sortKey="Maltais, Ja" uniqKey="Maltais J">JA Maltais</name></author><author><name sortKey="Weissman, Nj" uniqKey="Weissman N">NJ Weissman</name></author><author><name sortKey="Fitzgerald, Pj" uniqKey="Fitzgerald P">PJ Fitzgerald</name></author><author><name sortKey="Brewer, Hb" uniqKey="Brewer H">HB Brewer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keyserling, Ch" uniqKey="Keyserling C">CH Keyserling</name></author><author><name sortKey="Hunt, Tl" uniqKey="Hunt T">TL Hunt</name></author><author><name sortKey="Klepp, Hm" uniqKey="Klepp H">HM Klepp</name></author><author><name sortKey="Scott, Ra" uniqKey="Scott R">RA Scott</name></author><author><name sortKey="Barbaras, R" uniqKey="Barbaras R">R Barbaras</name></author><author><name sortKey="Schwenderman, A" uniqKey="Schwenderman A">A Schwenderman</name></author><author><name sortKey="Lalwani, N" uniqKey="Lalwani N">N Lalwani</name></author><author><name sortKey="Dasseux, Jl" uniqKey="Dasseux J">JL Dasseux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tardif, Jc" uniqKey="Tardif J">JC Tardif</name></author><author><name sortKey="Gregoire, J" uniqKey="Gregoire J">J Grégoire</name></author><author><name sortKey="Lesperance, J" uniqKey="Lesperance J">J Lespérance</name></author><author><name sortKey="Lambert, J" uniqKey="Lambert J">J Lambert</name></author><author><name sortKey="L Allier, Pl" uniqKey="L Allier P">PL L'Allier</name></author><author><name sortKey="Rodes, J" uniqKey="Rodes J">J Rodés</name></author><author><name sortKey="Anderson, T" uniqKey="Anderson T">T Anderson</name></author><author><name sortKey="Blue, Jw" uniqKey="Blue J">JW Blue</name></author><author><name sortKey="Imus, J" uniqKey="Imus J">J Imus</name></author><author><name sortKey="Heinonen, T" uniqKey="Heinonen T">T Heinonen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tardif, Jc" uniqKey="Tardif J">JC Tardif</name></author><author><name sortKey="Gregoire, J" uniqKey="Gregoire J">J Grégoire</name></author><author><name sortKey="L Allier, Pl" uniqKey="L Allier P">PL L'Allier</name></author><author><name sortKey="Anderson, Tj" uniqKey="Anderson T">TJ Anderson</name></author><author><name sortKey="Bertrand, O" uniqKey="Bertrand O">O Bertrand</name></author><author><name sortKey="Reeves, F" uniqKey="Reeves F">F Reeves</name></author><author><name sortKey="Title, Lm" uniqKey="Title L">LM Title</name></author><author><name sortKey="Alfonso, F" uniqKey="Alfonso F">F Alfonso</name></author><author><name sortKey="Schampaert, E" uniqKey="Schampaert E">E Schampaert</name></author><author><name sortKey="Hassan, A" uniqKey="Hassan A">A Hassan</name></author><author><name sortKey="Mclain, R" uniqKey="Mclain R">R McLain</name></author><author><name sortKey="Pressler, Ml" uniqKey="Pressler M">ML Pressler</name></author><author><name sortKey="Ibrahim, R" uniqKey="Ibrahim R">R Ibrahim</name></author><author><name sortKey="Lesperance, J" uniqKey="Lesperance J">J Lespérance</name></author><author><name sortKey="Blue, J" uniqKey="Blue J">J Blue</name></author><author><name sortKey="Heinonen, T" uniqKey="Heinonen T">T Heinonen</name></author><author><name sortKey="Rodes Cabau, J" uniqKey="Rodes Cabau J">J Rodés-Cabau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tardif, Jc" uniqKey="Tardif J">JC Tardif</name></author><author><name sortKey="Gregoire, J" uniqKey="Gregoire J">J Grégoire</name></author><author><name sortKey="Schwartz, L" uniqKey="Schwartz L">L Schwartz</name></author><author><name sortKey="Title, L" uniqKey="Title L">L Title</name></author><author><name sortKey="Laramee, L" uniqKey="Laramee L">L Laramée</name></author><author><name sortKey="Reeves, F" uniqKey="Reeves F">F Reeves</name></author><author><name sortKey="Lesperance, J" uniqKey="Lesperance J">J Lespérance</name></author><author><name sortKey="Bourassa, Mg" uniqKey="Bourassa M">MG Bourassa</name></author><author><name sortKey="L Allier, Pl" uniqKey="L Allier P">PL L'Allier</name></author><author><name sortKey="Glass, M" uniqKey="Glass M">M Glass</name></author><author><name sortKey="Lambert, J" uniqKey="Lambert J">J Lambert</name></author><author><name sortKey="Guertin, Mc" uniqKey="Guertin M">MC Guertin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berry, C" uniqKey="Berry C">C Berry</name></author><author><name sortKey="L Allier, Pl" uniqKey="L Allier P">PL L'Allier</name></author><author><name sortKey="Gregoire, J" uniqKey="Gregoire J">J Grégoire</name></author><author><name sortKey="Lesperance, J" uniqKey="Lesperance J">J Lespérance</name></author><author><name sortKey="Levesque, S" uniqKey="Levesque S">S Levesque</name></author><author><name sortKey="Ibrahim, R" uniqKey="Ibrahim R">R Ibrahim</name></author><author><name sortKey="Tardif, Jc" uniqKey="Tardif J">JC Tardif</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cote, G" uniqKey="Cote G">G Côté</name></author><author><name sortKey="Tardif, Jc" uniqKey="Tardif J">JC Tardif</name></author><author><name sortKey="Lesperance, J" uniqKey="Lesperance J">J Lespérance</name></author><author><name sortKey="Lambert, J" uniqKey="Lambert J">J Lambert</name></author><author><name sortKey="Bourassa, M" uniqKey="Bourassa M">M Bourassa</name></author><author><name sortKey="Bonan, R" uniqKey="Bonan R">R Bonan</name></author><author><name sortKey="Gosselin, G" uniqKey="Gosselin G">G Gosselin</name></author><author><name sortKey="Joyal, M" uniqKey="Joyal M">M Joyal</name></author><author><name sortKey="Tanguay, Jf" uniqKey="Tanguay J">JF Tanguay</name></author><author><name sortKey="Nattel, S" uniqKey="Nattel S">S Nattel</name></author><author><name sortKey="Gallo, R" uniqKey="Gallo R">R Gallo</name></author><author><name sortKey="Crepeau, J" uniqKey="Crepeau J">J Crépeau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mintz, Gs" uniqKey="Mintz G">GS Mintz</name></author><author><name sortKey="Garcia Garcia, Hm" uniqKey="Garcia Garcia H">HM Garcia-Garcia</name></author><author><name sortKey="Nicholls, Sj" uniqKey="Nicholls S">SJ Nicholls</name></author><author><name sortKey="Weissman, Nj" uniqKey="Weissman N">NJ Weissman</name></author><author><name sortKey="Tardif, Jc" uniqKey="Tardif J">JC Tardif</name></author><author><name sortKey="Serruys, Pw" uniqKey="Serruys P">PW Serruys</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Waters, D" uniqKey="Waters D">D Waters</name></author><author><name sortKey="Higginson, L" uniqKey="Higginson L">L Higginson</name></author><author><name sortKey="Gladstone, P" uniqKey="Gladstone P">P Gladstone</name></author><author><name sortKey="Kimball, B" uniqKey="Kimball B">B Kimball</name></author><author><name sortKey="Le May, M" uniqKey="Le May M">M Le May</name></author><author><name sortKey="Boccuzzi, Sj" uniqKey="Boccuzzi S">SJ Boccuzzi</name></author><author><name sortKey="Lesperance, J" uniqKey="Lesperance J">J Lespérance</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tardif, Jc" uniqKey="Tardif J">JC Tardif</name></author><author><name sortKey="Cote, G" uniqKey="Cote G">G Cöté</name></author><author><name sortKey="Lesperance, J" uniqKey="Lesperance J">J Lespérance</name></author><author><name sortKey="Bourassa, M" uniqKey="Bourassa M">M Bourassa</name></author><author><name sortKey="Lambert, J" uniqKey="Lambert J">J Lambert</name></author><author><name sortKey="Doucet, S" uniqKey="Doucet S">S Doucet</name></author><author><name sortKey="Bilodeau, L" uniqKey="Bilodeau L">L Bilodeau</name></author><author><name sortKey="Nattel, S" uniqKey="Nattel S">S Nattel</name></author><author><name sortKey="De Guise, P" uniqKey="De Guise P">P de Guise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Solymoss, Bc" uniqKey="Solymoss B">BC Solymoss</name></author><author><name sortKey="Bourassa, Mg" uniqKey="Bourassa M">MG Bourassa</name></author><author><name sortKey="Campeau, L" uniqKey="Campeau L">L Campeau</name></author><author><name sortKey="Sniderman, A" uniqKey="Sniderman A">A Sniderman</name></author><author><name sortKey="Marcil, M" uniqKey="Marcil M">M Marcil</name></author><author><name sortKey="Lesperance, J" uniqKey="Lesperance J">J Lespérance</name></author><author><name sortKey="Levesque, S" uniqKey="Levesque S">S Lévesque</name></author><author><name sortKey="Varga, S" uniqKey="Varga S">S Varga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barter, Pj" uniqKey="Barter P">PJ Barter</name></author><author><name sortKey="Baker, Pw" uniqKey="Baker P">PW Baker</name></author><author><name sortKey="Rye, Ka" uniqKey="Rye K">KA Rye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riwanto, M" uniqKey="Riwanto M">M Riwanto</name></author><author><name sortKey="Rohrer, L" uniqKey="Rohrer L">L Rohrer</name></author><author><name sortKey="Roschitzki, B" uniqKey="Roschitzki B">B Roschitzki</name></author><author><name sortKey="Besler, C" uniqKey="Besler C">C Besler</name></author><author><name sortKey="Mocharla, P" uniqKey="Mocharla P">P Mocharla</name></author><author><name sortKey="Mueller, M" uniqKey="Mueller M">M Mueller</name></author><author><name sortKey="Perisa, D" uniqKey="Perisa D">D Perisa</name></author><author><name sortKey="Heinrich, K" uniqKey="Heinrich K">K Heinrich</name></author><author><name sortKey="Altwegg, L" uniqKey="Altwegg L">L Altwegg</name></author><author><name sortKey="Von Eckardstein, A" uniqKey="Von Eckardstein A">A von Eckardstein</name></author><author><name sortKey="Luscher, Tf" uniqKey="Luscher T">TF Lüscher</name></author><author><name sortKey="Landmesser, U" uniqKey="Landmesser U">U Landmesser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alam, K" uniqKey="Alam K">K Alam</name></author><author><name sortKey="Meidell, Rs" uniqKey="Meidell R">RS Meidell</name></author><author><name sortKey="Spady, Dk" uniqKey="Spady D">DK Spady</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ballantyne, Christie M" sort="Ballantyne, Christie M" uniqKey="Ballantyne C" first="Christie M." last="Ballantyne">Christie M. Ballantyne</name><name sortKey="Barter, Philip" sort="Barter, Philip" uniqKey="Barter P" first="Philip" last="Barter">Philip Barter</name><name sortKey="Dasseux, Jean Louis" sort="Dasseux, Jean Louis" uniqKey="Dasseux J" first="Jean-Louis" last="Dasseux">Jean-Louis Dasseux</name><name sortKey="Fayad, Zahi A" sort="Fayad, Zahi A" uniqKey="Fayad Z" first="Zahi A." last="Fayad">Zahi A. Fayad</name><name sortKey="Guertin, Marie Claude" sort="Guertin, Marie Claude" uniqKey="Guertin M" first="Marie-Claude" last="Guertin">Marie-Claude Guertin</name><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J. P." last="Kastelein">John J. P. Kastelein</name><name sortKey="Keyserling, Constance" sort="Keyserling, Constance" uniqKey="Keyserling C" first="Constance" last="Keyserling">Constance Keyserling</name><name sortKey="Klepp, Heather" sort="Klepp, Heather" uniqKey="Klepp H" first="Heather" last="Klepp">Heather Klepp</name><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><name sortKey="L Allier, Philippe L" sort="L Allier, Philippe L" uniqKey="L Allier P" first="Philippe L." last="L'Allier">Philippe L. L'Allier</name><name sortKey="Lesperance, Jacques" sort="Lesperance, Jacques" uniqKey="Lesperance J" first="Jacques" last="Lespérance">Jacques Lespérance</name><name sortKey="Luscher, Thomas F" sort="Luscher, Thomas F" uniqKey="Luscher T" first="Thomas F." last="Lüscher">Thomas F. Lüscher</name><name sortKey="Paolini, John F" sort="Paolini, John F" uniqKey="Paolini J" first="John F." last="Paolini">John F. Paolini</name><name sortKey="Tardif, Jean Claude" sort="Tardif, Jean Claude" uniqKey="Tardif J" first="Jean-Claude" last="Tardif">Jean-Claude Tardif</name><name sortKey="Tawakol, Ahmed" sort="Tawakol, Ahmed" uniqKey="Tawakol A" first="Ahmed" last="Tawakol">Ahmed Tawakol</name><name sortKey="Waters, David D" sort="Waters, David D" uniqKey="Waters D" first="David D." last="Waters">David D. Waters</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003996 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003996 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4258222
|texte= Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial†
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24780501" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |